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Most Respected Viewers ! its all about the Types/ Risk / Factors / Symptoms / Screening Treatment & Prevention What Is Down Syndrome? Down syndrome (sometimes spelled “Down’s syndrome”) is a genetic abnormality. It is the most common single cause of birth defects in the United States This syndrome occurs because of an extra copy of chromosome 21. Your chromosomes contain your genetic material, & any problems with your chromosomes can cause serious physical and mental health problems Down syndrome causes lifelong developmental delays that can range from moderate to severe. It cannot be cured, but there are options. Down syndrome can be managed with educational interventions, specialized parenting techniques, and community engagement. These all can encourage a person with Down syndrome to develop life skills and social bonds, so that they can live a long (many Down syndrome patients live past the age of 50) and fulfilling life. Causes What Causes Down Syndrome? Down syndrome is e genetic disorder. TO understand how it happens, we first need to understand some basic genetics. In all cases of reproduction, both parents pass their genes on to their children. These genes are carried on chromosomes. When the baby’s cells develop, each cell is supposed to receive 23 pairs of chromosomes. Half of the chromosomes are from the mother and half from the father. In children with Down syndrome, one of the chromosomes does not separate properly. The baby ends up with three copies of chromosome 21 instead of two. This extra chromosome causes problems as the brain and physical features develop. Types Types of Down Syndrome There are three types of Down syndrome: Trisomy 21 Trisomy 21 means there is an extra copy of chromosome 21 in every cell. This is the most common form of Down syndrome. Mosaicism Mosaicism means there is an extra chromosome in some but not all of a child’s cells. Individuals with mosaic Down syndrome tend to have fewer symptoms. Translocation In this condition, children have only an extra part of chromosome 21. There are 46 total chromosomes. However, one of them has an extra piece of chromosome 21 attached. Risk Factors Will My Child Be at Risk for Down Syndrome? Certain parents have a greater risk of giving birth to a child with Down syndrome: women age 35 and older males 50 and older people with a family history of Down’s syndrome people who carry the genetic translocation Symptoms What Are the Symptoms of Down Syndrome? During pregnancy, there are no signs that a child will have Down syndrome. At birth, babies with Down syndrome usually have certain characteristic signs, including: flat facial features small head and ears short neck bulging tongue eyes that slant upward oddly shaped ears poor muscle tone A Down syndrome infant can be born a normal size. However development is twice as slow as for an unaffected child. There is usually some degree of mental retardation, but it is often mild to moderate. Mental and social development delays may mean that the child will have: impulsive behavior poor judgment short attention span slow learning capabilities Medical complications often accompany Down syndrome. These are caused by the extra chromosome. These may include: congenital heart defects hearing loss poor vision cataracts (clouded eyes) hip problems, such as dislocations leukemia chronic constipation sleep apnea (interrupted breathing during sleep) dementia (thought and memory problems) hypothyroidism (low thyroid function) obesity late tooth growth, causing problems with chewing Today, despite the medical and developmental delays, a child born with Down syndrome can live past the age of 50 (Mayo Clinic). Screening Screening for Down Syndrome During Pregnancy Screening is offered as a routine part of prenatal care in the United States. However, it is not required. First Trimester An ultrasound evaluation and blood tests can look for Down syndrome in your fetus. These tests are done between the 10th and 14th week of pregnancy. An ultrasound looks at the back of the baby’s neck, called the nuchal translucency. If there are problems with the baby’s development, more fluid collects in this area. Blood tests looks at the level of pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotropin (HCG). High levels of these proteins suggest a developmental problem. These tests have a higher false-positive rate than tests done at later pregnancy stages. If results are not normal, your doctor may follow up with an amniocentesis. In this test, an amniotic fluid sample is used to confirm the results. Second Trimester An ultrasound and quadruple marker screen (QMS) test can help identify Down syndrome and other neural tube defects. This test is done between 15 and 20 weeks. These tests measures four pregnancy-related factors: human chorionic gonadotropin (HCG) unconjugated estriol alpha-fetoprotein (AFP) inhibin-A If any of these tests are not normal, you will be considered at high risk for birth defects. Additional Prenatal Tests Your doctor may order additional tests to detect Down syndrome in your baby: amniocentesis: Your doctor takes a sample of amniotic fluid to examine the number of chromosomes the baby has. The test is usually done at 15 weeks. It carries a one in 200 miscarriage risk. chorionic villus sampling (CVS): Your doctor will take cells from your placenta to analyze fetal chromosomes. This test is done during the ninth and 14th week of pregnancy. It carries a miscarriage risk of one in 100. percutaneous umbilical blood sampling (PUBS): Your doctor will take blood from the umbilical cord and examine it for chromosomal defects. It is done after the 18th week of pregnancy. It carries an even higher rate of miscarriage, so it is performed only if all other tests are uncertain. Some women choose not to undergo these tests, because of the risk of miscarriage. They would rather risk having a child with Down syndrome than losing the pregnancy. Tests at Birth At birth, your doctor will: perform a physical examination of your baby order a blood test called a karyotype to confirm Down syndrome Treatment Treating Down Syndrome There is no cure for Down syndrome. However, parents can provide early intervention and opportunities to help their child with Down syndrome succeed. Early intervention programs promote a child’s learning. They offer the best chance for success. In these programs, special education teachers and therapists will help your child learn: sensory skills social skills self-help motor skills language and cognitive abilities Children with Down syndrome often meet age-related milestones. However, this may take up to two times longer than for other children. A team of physicians and specialists can help provide medical care and manage the medical complications. Because obesity can be particularly dangerous to the health of children with Down syndrome, it is important to encourage physical activity and avoid high-calorie foods. However, before beginning exercise or sports, the child’s hip, neck, and spine should be examined. It is important to teach children with Down syndrome about being independent and staying safe. Parents should establish a support network in the family and community. Learn as much as possible about your child’s condition. This can help you understand what it means as your child grows and develops. Many people with Down syndrome lead successful lives in their community. They often go to school, hold jobs, and become independent. Prevention Preventing Down Syndrome There is no way to prevent Down syndrome. You may want to speak with a genetic counselor: before having a child, to see if you are at risk if you already have a child with Down syndrome and are considering getting pregnant again Regards from' Oxfordcadets Team J Block Firdos Market Gulberg iii Lahore skype id oxfordcadets g mail oxfordcadets at g mail dot com whatsapp +92 333 4/6/3/3/9/9/0 Get Updates on + 92 342 37 2 5 129

WE have made arrangements for the provision of quality legal services to the all people without any discrimination between rich and poor common man. Legal aid for the poor, needy, victims and oppressed We provide legal assistance, practical support and shelter for victims of abuse, poor people and women in need of legal support. WE have a team of legal experts who is literally turning the tide on oppression by providing the legal assistance to the real victims. We also help victims lodge criminal and civil complaints, compile evidence to help support cases, and supply victims with experienced lawyers. In addition, WE are actively campaigning to see changes to the law that will secure justice and equality for all of Pakistanis irrespective of their cast, creed or religion. Our efforts have led to hundreds of cases against citizens being dropped and lives saved each year. Over and above legal assistance, we provide support to the provision of safe and humanitarian aid for victims. Free Legal consultation and Aid is available on Family laws, Property matters, Civil and criminal proceedings, Contracts and agreements, and legal guardian’s matters, etc. It is aimed to fulfil the need of legal help for Pakistanis according to Pakistani laws such as Rent laws, Transfer of Property law, law of Succession, Family laws, Law of inheritance and Specific relief Act etc. They further offer services in fields of Commercial law including law of Contract. Views: 12

The policeman is a useful government servant. He wears black shirt ad khaki pant. He ties a belt round his waist and keeps a black cap on his head. The policeman is responsible person. He is responsible for keeping law and order in the locality. He is the guardian of the life and property of the people. He arrests thieves, smugglers and criminals. In his absence there is no place for the poor or weak. The policeman performs his duty everywhere. There is not a single place where he cannot go. In big cities he can be seen controlling the traffic. He can be seen at railway stations, bus stands, banks and post offices. He performs his patrol duty on all roads and bazaars. He goes where there is a gathering. It is a fact that policeman is usually rude. He is uneducated. Gentlemen are treated harshly by him. He considers poor people as animals. He gives preference to himself because he has stick with him. He has no pity of others. Receiving bribes is his common practice. The job of a policeman is very difficult. He is on duty round the clock. He puts his life in danger while fighting against criminals, as he gets a small salary, his standard of living is low. It is very difficult for him to support a large family with that little income. The government should pay attention to the life of a policeman. His salary must be increased so that he may not be compelled to receive bribes.

When young families decoration on the floor requirements are: spend less, good care, point the better looks nice. Strengthen the floor just to meet the needs of young couples, not only that, laminate wood plastic composite decking belgium flooring are to color, good performance and are more and more decoration family favorite. Solid wood flooring and solid wood, parquet flooring, compared laminate flooring in the comfort to handicap. But because it is man-made, and therefore have a solid wood floor you do not have a lot of advantages: First, good wear resistance: strengthening the floor surface wear layer is specially treated, can achieve high hardness, that the use of a sharp hard objects such as keys to scratch, it will not leave marks. The greatest benefit of this advantage is that, in everyday life no longer have to protect the floor and the timid. Second, resistance to stains: stains out on the surface of wood materials, it is easy to penetrate it, no longer difficult to clean. And strengthen the floor surface is 16 X 20 Terrace Deck Kit completely without this trouble. Since the surface is a special material, even if the ink drops down, it will not penetrate it, can only stay on the surface, you can drag with a mop to clean up. Third, good care: wear, dirt floor, take care of them natural and convenient. Even for some time do not care, do not worry the floor will be compromised. This is, for the usual busy young families particularly useful. Fourth, low price and less trouble: When wood flooring prices are still rising, when laminate flooring prices are gradually going down, now on the market in general to strengthen the floor with 90 yuan / square meter price can buy, count down, the budget spent on the floor can save a lot. Also due to the strengthening of simple floor installation, easy maintenance, trouble caused by the floor naturally less. Fifth, the style is more easy to match: artificial outdoor revolution versa tile flooring tiles floor style more elegant young couples can choose to buy like this. Strengthen disadvantage floor: First, poor comfort: strengthening thickness of the floor is usually less than 1mm, and the materials used are artificial, and therefore almost natural comfort. But this problem should look like this: Laminate flooring comfort is not good enough, but its price is only 1/4 or less of solid wood flooring, laminate flooring and the advantages that are not exactly solid wood flooring, not all people regard the floor in the election of comfort in the first place. Views: 125

"We are cleaning specialists of all types of Domestic and Industrial water storage tanks. These include concrete, plastic, poly, fiberglass, & galvanized iron water tanks. We can improve poor water quality; ie. smelly, bad tasting, tainted, or discolored drinking water, and guarantee to remove the buildup of sediment from the floor of your water tank even when its full, leaving you and your family with clean, clear, and safe water. Water Tank Cleaning with Medicines Underground and overhead tanks are cleaned hygienically and scientifically with medicines. Contact: 0333-2628888 For More Detail: acmeservicespk" Views: 101